Name: BCL6B抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)： BCL6B抗原（重組蛋白）

英文名稱(chēng)： BCL6B Antigen (Recombinant Protein)

別名： B-cell CLL/lymphoma 6B; BAZF; ZNF62; ZBTB28

相關(guān)類(lèi)別：抗原

儲(chǔ) 存： 冷凍（-20℃）

概述

Fusion protein corresponding to a region derived from 280-479 amino acids of human BCL6B

技術(shù)規(guī)格

Full name:	B-cell CLL/lymphoma 6B
Synonyms:	BAZF; ZNF62; ZBTB28
Swissprot:	Q8N143
Gene Accession:	BC059404
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NF?B expression, thereby inhibiting NF?B-mediated cellular functions. Bcl-6b (B-cell CLL/lymphoma 6, member B), also known as ZNF62, BAZF or ZBTB28, is a 480 amino acid nuclear protein that contains one BTB (POZ) domain and five C2H2-type zinc fingers. Expressed ubiquitously with highest expression in placenta and heart, Bcl-6b associates with Bcl-6 and functions as a sequence-specific transcriptional repressor that is thought to be necessary for early B-cell development. The gene encoding Bcl-6b maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.

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