Name: SPDL1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： SPDL1抗原（重組蛋白）

英文名稱： SPDL1 Antigen (Recombinant Protein)

別名： CCDC99

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Fusion protein corresponding to C terminal 250 amino acids of human SPDL1

技術(shù)規(guī)格

Full name:	Spindle apparatus coiled-coil protein 1
Synonyms:	CCDC99
Swissprot:	Q96EA4
Gene Accession:	BC012568
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.

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