Name: PTRH2 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)： PTRH2 抗原（重組蛋白）

英文名稱(chēng)： PTRH2 Antigen (Recombinant Protein)

別名： peptidyl-tRNA hydrolase 2; BIT1; PTH2; CFAP37; CGI-147

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別： 抗原

概述

Fusion protein corresponding to a region derived from 63-179 amino acids of human PTRH2

技術(shù)規(guī)格

Full name:	peptidyl-tRNA hydrolase 2
Synonyms:	BIT1; PTH2; CFAP37; CGI-147
Swissprot:	Q9Y3E5
Gene Accession:	BC006807
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	PTRH2 (peptidyl-tRNA hydrolase 2), also known as BIT1 (Bcl-2 inhibitor of transcription 1), is a 179 amino acid mitochondrial protein. During apoptosis, PTRH2 is released from the mitochondia to the cytoplasm. Once in the cytoplasm, PTRH2 regulates the function of two transcriptional regulators, TLE5 and TLE1, thereby promoting caspase-independent cell death. It is also believed that the natural substrate for PTRH2 may be petidyl-tRNAs, which leave the ribosomes during protein synthesis.

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