Name: NANOS2抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： NANOS2抗原（重組蛋白）

英文名稱： NANOS2 Antigen (Recombinant Protein)

別名： NOS2; ZC2HC12B

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Full length fusion protein

技術規(guī)格

Full name:	nanos C2HC-type zinc finger 2
Synonyms:	NOS2; ZC2HC12B
Swissprot:	P60321
Gene Accession:	BC117484
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

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