Name: CDC45 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： CDC45 抗原（重組蛋白）

英文名稱：CDC45 Antigen (Recombinant Protein)

別名： cell division cycle 45; CDC45L; CDC45L2; PORC-PI-1

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別：抗原

概述

Fusion protein corresponding to a region derived from 367-566 amino acids of human CDC45

技術(shù)規(guī)格

Full name:	cell division cycle 45
Synonyms:	CDC45L; CDC45L2; PORC-PI-1
Swissprot:	O75419
Gene Accession:	BC006232
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants.

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