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021-54845833/15800441009
中文名稱：兔抗CBL多克隆抗體
英文名稱： Anti-CBL rabbit polyclonal antibody
相關(guān)類(lèi)別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： CBL
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
克隆類(lèi)型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder |
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Applications: |
ELISA, WB |
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Name of antibody: |
CBL |
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Immunogen: |
Synthetic peptide of human CBL |
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Full name: |
Cbl proto-oncogene, E3 ubiquitin protein ligase |
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Synonyms： |
CBL2; NSLL; C-CBL; RNF55; FRA11B |
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SwissProt: |
P22681 |
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ELISA Recommended dilution: |
2000-5000 |
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WB Predicted band size: |
100 kDa |
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WB Positive control: |
231 cells |
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WB Recommended dilution: |
500-2000 |
