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中文名稱： 兔抗MDM2 (phospho-Ser166)多克隆抗體
英文名稱： Anti-MDM2 (phospho-Ser166) rabbit polyclonal antibody
別 名： HDMX; hdm2; ACTFS
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： MDM2 (phospho-Ser166)
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
MDM2 (phospho-Ser166) |
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Immunogen: |
Synthetic peptide of human MDM2 (phospho-Ser166) |
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Full name: |
MDM2 oncogene, E3 ubiquitin protein ligase (phospho-Ser166) |
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Synonyms： |
HDMX; hdm2; ACTFS |
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SwissProt: |
Q00987 |
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IHC positive control: |
Human breast carcinoma |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
90 kDa |
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WB Positive control: |
293 cells treated with Hydroxyurea |
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WB Recommended dilution: |
500-1000 |
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IF Positive control: |
Hela cells |
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IF Recommended dilution |
100-200 |
