購物車
幫助
021-54845833/15800441009
中文名稱：兔抗SGOL1多克隆抗體
英文名稱： Anti-SGOL1 rabbit polyclonal antibody
別 名： SGO; Sgo1; NY-BR-85
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
抗 原： SGOL1
宿 主： Rabbit
反應(yīng)種屬： Human
標(biāo)記物： Unconjugate
克隆類型： Unconjugate
技術(shù)規(guī)格
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Background: |
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. |
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Applications: |
WB |
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Name of antibody: |
SGOL1 |
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Immunogen: |
Synthesized peptide derived from internal of human SGOL1. |
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Full name: |
shugoshin-like 1 |
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Synonyms： |
SGO; Sgo1; NY-BR-85 |
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SwissProt: |
Q5FBB7 |
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WB Predicted band size: |
64 kDa |
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WB Positive control: |
Hela cells lysate |
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WB Recommended dilution: |
500-3000 |
