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中文名稱：BCL2L15抗原（重組蛋白）
英文名稱：BCL2L15 Antigen (Recombinant Protein)
儲 存：冷凍（-20℃）
相關類別：抗原
概述
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Fusion protein corresponding to a region derived from 1-163 amino acids of human BCL2L15 |
技術規(guī)格
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Full name: |
BCL2 like 15 |
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Synonyms: |
Bfk; C1orf178 |
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Swissprot: |
Q5TBC7 |
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Gene Accession: |
BC127719 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1-3), while BH3-only proteins, like Bim, possess only the short BH3 motif. Database searches revealed Bfk, an unusual novel member of the Bcl-2 family that contains a BH2 and BH3 region but not BH1 or BH4. Bfk is thus most closely related to Bcl-G(L). It lacks a C-terminal membrane anchor and is cytosolic. Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function. Like Bcl-G(L), Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins. Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development. |
