購(gòu)物車
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021-54845833/15800441009
中文名稱： 兔抗PTPN13多克隆抗體
英文名稱： Anti-PTPN13 rabbit polyclonal antibody
別 名： PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： PTPN13
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
PTPN13 |
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Immunogen: |
Synthetic peptide of human PTPN13 |
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Full name: |
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) |
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Synonyms： |
PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS |
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SwissProt: |
Q12923 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human cervical cancer and Human brain |
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IHC Recommend dilution: |
25-100 |
