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中文名稱： 兔抗RING1多克隆抗體
英文名稱： Anti-RING1 rabbit polyclonal antibody
別 名： RNF1; RING1A
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： RING1
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. |
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Applications: |
WB |
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Name of antibody: |
RING1 |
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Immunogen: |
Synthetic peptide of human RING1 |
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Full name: |
ring finger protein 1 |
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Synonyms： |
RNF1; RING1A |
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SwissProt: |
Q06587 |
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WB Predicted band size: |
42 kDa |
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WB Positive control: |
Hela cells |
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WB Recommended dilution: |
500-1000 |
